The Covid-19 vaccine portal has opened for 49-year-olds to register.
High-risk patients and frontline healthcare workers who have yet to receive an appointment can also register.
People can sign up by phone or online and will be given Pfizer or Moderna when vaccinations start later this month.
However, it's expected Johnson and Johnson and AstraZeneca will be offered if they aren't available at the time.
Consultant in Infectious Diseases at St James' Hospital in Dublin, Professor Cliona Ni Cheallaigh, says the choice will help speed up the vaccine programme:
It's brilliant to be giving people the choice,
"It allows people to make up their own minds whether they feel that the small risks of blood clots with AstraZeneca and Johnson and Johnson outweigh the risks of waiting longer to getting Pfizer or Moderna," she said.
To register for the vaccine online, and to find out more information you can go to https://vaccine.hse.ie/