Leinster's Sam Prendergast has been selected to start Ireland's 2025 Six Nations campaign by interim coach Simon Easterby.
The 21-year-old fly-half has been given the nod ahead of Munster's Jack Crowley. who has been named on the bench.
There is just one Munster player set to start the game in Second Row Tadhg Beirne.
Conor Murray and the aforementioned Crowley are named among the replacements.
Kick off is at 4.45pm at the Aviva Stadium.
Ireland
Backs: Hugo Keenan; Mack Hansen; Garry Ringrose, Bundee Aki, James Lowe; Sam Prendergast, Jamison Gibson-Park
Forwards: Andrew Porter, Rónan Kelleher, Finlay Bealham; James Ryan, Tadhg Beirne; Ryan Baird, Josh Van Der Flier, Caelan Doris (Captain)
Replacements: Dan Sheehan, Cian Healy, Thomas Clarkson, Iain Henderson, Jack Conan, Conor Murray, Jack Crowley, Robbie Henshaw
England
Backs: Freddie Steward; Tommie Freeman, Henry Slade, Ollie Lawrence, Caden Murley; Marcus Smith, Alex Mitchell
Forwards: Ellis Genge, Luke Cowan-Dickie, Will Stuart; Maro Itoje (Captain), George Martin; Tom Curry, Ben Curry, Ben Earl
Replacements: Theo Dan, Fin Baxter, Joe Heyes, Ollie Chessum, Chandler Cunningham-South, Tom Willis, Harry Randall, Fin Smith
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