Manchester United face a battle to qualify for the knock out stages of the Champions League.
The Red Devils were beaten 1-nil by Juventus at Old Trafford last night.
Paulo Dybala scored from close range following a cross from former United striker Christiano Ronaldo.
The sides meet against in Turin in a fortnight, but the Italians are already are five points clear of United at the top of Group H.
Red Devils boss Jose Mourinho admits there is a gulf between the two clubs.
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Manchester City stormed to the top of the Group F with a comfortable 3-nil victory over Shakhtar Donetsk in Ukraine.
It is the first time Shakhtar have lost a home European tie to English opposition.
City top of the Pool after Hoffenheim and Lyon played out a dramatic 3-all draw in Germany.
Pep Guardiola is happy with the way his side have bounced back after loosing their opening match.
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Sadio Mane could be back in the Liverpool team for tonight's Pool C encounter with Red Star Belgrade at Anfield.
The Senegalese international missed Saturday's win over Huddersfield with a hand injury.
Manager Jurgen Klopp says he will be without captain Jordan Henderson and Naby Keita.
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Tottenham have injury concerns of their own ahead of their tea-time trip to P-S-V Eindhoven.
Dele Alli, Danny Rose and Jan Vertonghen will all miss the Group B game.
Barcelona are without Lionel Messi for the top of the table clash with Inter Milan at the Nou Camp.