Joe Schmidt has made four changes to his side to face hosts Japan at the Rugby World Cup on Saturday.
Connacht's Jack Carty has been selected to start at out-half with Jonny Sexton rested as he continues to nurse a muscle injury he picked up in their opener against Scotland.
It'll mark 27-year-old Carty's only second ever start in an Irish jersey - just over six months on from his senior debut.
Schmidt though feels he's ready for the test; "he's very calm, he stay in the zone incredibly well so for us with Jack, there's a lot of confidence not just from the coaching staff, but from the players as well".
Meanwhile, Rob Kearney has been passed fit to start at fullback, Keith Earls is back on the wing and Chris Farrell comes into the centre in place of Bundee Aki.
Jack Conan was due to start but has picked up an injury training this morning and is no longer available.
The Ireland team in full is: Rob Kearney, Keith Earls, Garry Ringrose, Chris Farrell, Jacob Stockdale, Jack Carty, Conor Murray.
CJ Stander, Josh van der Flier, Peter O'Mahony, James Ryan, Iain Henderson, Tadhg Furlong, Rory Best, Cian Healy.
#RWC2019
4 Changes for Ireland - @KearneyRob @KEITHEARLS87 @Farrell_C93 & @JackCarty10 #ShoulderToShoulder #JPNvIRE #TeamOfUs https://t.co/sX6DJcNBAB— Irish Rugby (@IrishRugby) September 26, 2019
This morning, Italy will hope to make it two-wins from two games in Pool B.
Conor O'Shea's side face Canada in Fukuoka at 8.45 Irish time.
While England are up against the USA in Pool C.
Kick-off in Kobe is at 11.45.
Episode 8 is here! @RugbyUruguay shock the rugby world! We get serious with @DimitriYachvili , put @ToddsClever to the test and catch up with Martin Johnson and @owen_faz .#RWC2019 #ENGvUSA pic.twitter.com/7EinfG7Sgu
— Rugby World Cup (@rugbyworldcup) September 26, 2019
