Ireland finish off their Six Nations campaign with a home game against last year's champions England at the Aviva Stadium, with kick off at 4:45pm.
After last week's game against Scotland, it was revealed that Ireland would be without the Leinster pair of James Ryan and Garry Ringrose due to injury.
Bundee Aki will come in at outside centre for the injured Ringrose while Tadhg Beirne and Iain Henderson are the second row pairing.
Ulster winger Jacob Stockdale also makes his return to the side after being out injured for a number of months.
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Team news, match build up, in-game stats and commentary - check our our match centre.#IREvENG #ShoulderToShoulderhttps://t.co/Qu2lnKaIuz pic.twitter.com/S7TB1BaIs7— Irish Rugby (@IrishRugby) March 18, 2021
Andy Farrell will look to finish the campaign with more wins than losses, as after a tough start with defeats to Wales and France, Ireland have won their last two games against Italy and Scotland.
Much of the build up to the game has centred around CJ Stander's decision to retire at the end of this season, meaning it will be his last Six Nations match.
The Munster forward has been a stalwart for the Irish team ever since his debut back in 2016. Despite only being 30, Stander made the decision to retire to spend more time with his family in South Africa.
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CJ’s farewell, Hugo Keenan exclusive, Gary Halpin & John Pullin remembered. #IREvENG #ShoulderToShoulder https://t.co/l9ecFrduBm? pic.twitter.com/T8R5laAXyX— Irish Rugby (@IrishRugby) March 20, 2021
Elsewhere, Scotland are currently 24-10 up against the Italians at Murrayfield. Gregor Townsend's men will looks to finish of the championship on a high.
The Six Nations decider between France and Wales takes place later this evening at 8pm. Wales will be going for the Grand Slam, while France will just be hoping to win the championship after losing to England last weekend.