People in Waterford City have a shorter life expectancy than those in parts of Dublin.
The National Deprivation Index for Ireland says people living in more deprived areas are at risk of dying younger.
The research by Trinity College Dublin found Waterford City is the second most deprived area of the country.
Limerick City is the most deprived area while Meath, Kildare, Galway and Clare are among the least deprived.
Catherine Darker, Professor of Health Services Research in Trinity College Dublin, says the report was compiled based on a number of factors:
"The indicators that go into the Deprivation Index looks at a range of different things. One of those things in relation to the citizens of Waterford; we found that Waterford City has the second highest values for unemployment and low social class, and also has the highest value of local authority housing."
County Waterford scored as one of the least deprived areas but Professor Darker says there are a few places that are deprived, including Ballydurn:
"From the previous census in 2011 to the most recent census in 2016, there's actually been a large dis-improvement in terms of the deprivation levels for the residents within that particular area of Waterford."